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KMID : 0385020010170040291
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Korean Journal of Laboratory Animal Science
2001 Volume.17 No. 4 p.291 ~ p.296
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Immunological Effect of Experimental Vibrio anguillarum Vaccine and its Safety in Fish
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허원/Huh, Won
권창희/조동윤/김용기/장용기/Kweon, Chang Hee/Cho, Dong Yoon/Kim, Yong Gee/Jang, Yong Gee
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Abstract
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Vibrio anguillarum bacterin was experimentally tested for the safety and efficacy in 5shes. When the fishes were immersed with experimental vaccine or intraperitoneally inoculated, the immune responses were detected within 2 weeks after second vaccination with the highest titer at 8 weeks post vaccination. In addition, the duration of immunity were detected more than 6 months after vaccination. In order to investigate the protective efficacy, the survival rate of 5shes were evaluated after challenge exposure from first week throughout 7 weeks post vaccination. Although 100% survival was evident from the group of intraperitoneal vaccination, however, the lower survival rate (60%) were detected from the immersed 5shes. Nevertheless, the higher survival rate than control (30%) were detected from the immersed fishes, confirming the presence of protective immunity. The present results indicate that Vibrio anguillarum vaccine can be safely applied as an effective prophylatic method to prevent the economic losses from clinical vibriosis.
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KEYWORD
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